CBCS RGPV 4th Sem Pharma Syllabus | RGPV B Pharma Syllabus 4th Sem 2nd Year
Now RGPV announced the 2nd year 4th sem Pharmacy syllabus. In this Scheme there are 6 subjects with practicals. The RGPV CBCS 4th Sem B Pharma syllabus of 6 subjects are as follows:
RGPV CBCS 4th Sem Pharmacy Subject list
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PY 401
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Pharma Chemistry iv
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PY 402
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Medicinal Chemistry -1
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PY 403
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Pharmaceutical Analysis
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PY 404
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Pharmacology -1
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PY 405
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Pharmaceutical Engg
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PY 406
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Pathophysiology
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Click to >> Download RGPV CBCS 4th Sem B Pharma Practical Syllabus
RGPV CBCS Pharma Chemistry iv Syllabus >>>
- RGPV CBCS Pharmaceutical Chemistry Syllabus
PY-401 :PHARMACEUTICAL CHEMISTRY-IV (ORGANICCHEMISTRY-III)Stereo isomerism
Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds
Elements of symmetry, chiral and achiral molecules, DL system of nomenclature of optical
isomers, sequence rules, RS system of nomenclature of optical isomers. Reactions of chiral
molecules, Racemic modification and resolution of racemic mixture. Asymmetric synthesis:
partial and absolute.
Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems), Methods of
determination of configuration of geometrical isomers. Conformational isomerism in Ethane, nButane
and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and
conditions for optical activity. Stereospecific and stereoselective reactions.
Heterocyclic compounds:
Nomenclature and classification, Synthesis, reactions and medicinal uses of following
compounds/derivatives Pyrrole, Furan, and Thiophene - Relative aromaticity, reactivity and
Basicity of pyrrole,
Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrazole,
Imidazole, Oxazole and Thiazole, Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity
of pyridine, synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
Reactions of synthetic importance
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff
Kishner reduction. Oppenauer-oxidation and Dakin reaction. Beckmanns rearrangement and
Schmidt rearrangement. Claisen-Schmidt condensation.
- RGPV CBCS Medicinal Chemistry -1 Syllabus
Introduction to Medicinal Chemistry
History and development of medicinal chemistry
Physicochemical properties in relation to biological action Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism.
Drug metabolism
Drug metabolism principles- Phase I and Phase II.
Factors affecting drug metabolism including stereo chemical aspects.
Drugs acting on Autonomic Nervous System
Adrenergic Neurotransmitters: Biosynthesis and catabolism of catecholamine.
Adrenergic receptors (Alpha & Beta) and their distribution.
Sympathomimetic agents: SAR of Sympathomimetic agents
Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, Methyldopa,Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine.
Agents with mixed mechanism: Ephedrine, Metaraminol.
Adrenergic Antagonists:
Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide.
Beta adrenergic blockers: SAR of beta blockers, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol.
Cholinergic neurotransmitters: Biosynthesis and catabolism of acetylcholine.
Cholinergic receptors (Muscarinic & Nicotinic) and their distribution. Parasympathomimetic agents: SAR of Parasympathomimetic agents
Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.
Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine,
Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.
Cholinesterase reactivator: Pralidoxime chloride.
Cholinergic Blocking agents: SAR of cholinolytic agents
Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine
hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.
Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium
bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline
bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine
hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.
Drugs acting on Central Nervous System
A. Sedatives and Hypnotics:
Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam,
Chlorazepate, Lorazepam, Alprazolam, Zolpidem
Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital,
Butabarbital, Pentobarbital, Secobarbital
Miscelleneous:
Amides & imides: Glutethmide.
Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol.
Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.
B. Antipsychotics
Phenothiazeines: SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine
hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride,
Prochlorperazine maleate, Trifluoperazine hydrochloride.
Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.
Fluro buterophenones: Haloperidol, Droperidol, Risperidone.
Beta amino ketones: Molindone hydrochloride.
Benzamides: Sulpieride.
C. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action
Barbiturates: Phenobarbitone, Methabarbital.
Hydantoins: Phenytoin*, Mephenytoin, Ethotoin
Oxazolidine diones: Trimethadione, Paramethadione
Succinimides: Phensuximide, Methsuximide, Ethosuximide*
Urea and monoacylureas: Phenacemide, Carbamazepine*
Benzodiazepines: Clonazepam
Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate
Drugs acting on Central Nervous System
General anesthetics:
Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.
Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental sodium.
Dissociative anesthetics: Ketamine hydrochloride.*
Narcotic and non-narcotic analgesics
Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine,
Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide
hydrochloride, Fentanyl citrate*, Methadone hydrochloride*, Propoxyphene hydrochloride,
Pentazocine, Levorphanol tartarate.
Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride.
Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate,
Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen,
Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.
- RGPV CBCS Pharmaceutical Analysis Syllabus
Pharmaceutical analysis- Definition and scope
i. Different techniques of analysis
ii. Methods of expressing concentration
iii. Primary and secondary standards.
iv. Preparation and standardization of various molar and normal solutions- Oxalic acid, sodium
hydroxide, hydrochloric acid, sodium thiosulphate, sulphuric acid, potassium permanganate
and ceric ammonium sulphate
Errors: Sources of errors, types of errors, methods of minimizing errors, accuracy, precision
and significant figures
Acid base titration: Theories of acid base indicators, classification of acid base titrations and
theory involved in titrations of strong, weak, and very weak acids and bases, neutralization
curves
Non aqueous titration: Solvents, acidimetry and alkalimetry titration and estimation of Sodium
benzoate and Ephedrine HCl
Gravimetry: Principle and steps involved in gravimetric analysis. Purity of the precipitate: coprecipitation
and post precipitation, Estimation of barium sulphate.
Precipitation titrations: Mohrs method, Volhard’s, Modified Volhard’s, Fajans method,
estimation of sodium chloride.
Complexometric titration: Classification, metal ion indicators, masking and demasking
reagents, estimation of Magnesium sulphate, and calcium gluconate.
Redox titrations: Concepts of oxidation and reduction, Types of redox titrations (Principles
and applications), Cerimetry, Iodimetry, Iodometry, Bromatometry, Dichrometry, Titration with
potassium iodate
Electrochemical methods of analysis
a) Conductometry- Introduction, Conductivity cell, Conductometric titrations, applications.
b) Potentiometry - Electrochemical cell, construction and working of reference (Standard
hydrogen, silver chloride electrode and calomel electrode) and indicator electrodes (metal
electrodes and glass electrode), methods to determine end point of potentiometric titration and
applications.
c) Polarography - Principle, Ilkovic equation, construction and working of dropping mercury
electrode and rotating platinum electrode, applications.
- RGPV CBCS Pharmacology -1 Syllabus
General Pharmacology
a. Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology,
nature and source of drugs, essential drugs concept and routes of drug administration, Agonists,
antagonists( competitive and non competitive), spare receptors, addiction, tolerance,
dependence, tachyphylaxis, idiosyncrasy, allergy.
b. Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of
drugs .Enzyme induction, enzyme inhibition, kinetics of elimination
General Pharmacology
a. Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories and
classification of receptors, regulation of receptors. drug receptors interactions signal
transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane
enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that
regulate transcription factors, dose response relationship, therapeutic index, combined effects of
drugs and factors modifying drug action.
b. Adverse drug reactions.
c. Drug interactions (pharmacokinetic and pharmacodynamic)
d. Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical
evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance.
Pharmacology of peripheral nervous system
a. Organization and function of ANS.
b. b.Neurohumoral transmission,co-transmission and classification of neurotransmitters.
c. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics.
d. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
e. Local anesthetic agents.
f. Drugs used in myasthenia gravis and glaucoma
rmacology of central nervous system
a. Neurohumoral transmission in the C.N.S.special emphasis on importance of various
neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.
b. General anesthetics and pre-anesthetics.
c. Sedatives, hypnotics and centrally acting muscle relaxants.
d. Anti-epileptics
e. Alcohols and disulfiram
Pharmacology of central nervous system
a. Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxiety agents, antimanics
and hallucinogens.
b. Drugs used in Parkinsons disease and Alzheimer’s disease.
c. CNS stimulants and nootropics.
d. Opioid analgesics and antagonists
e. Drug addiction, drug abuse, tolerance and dependence.
- RGPV CBCS Pharmaceutical Engg Syllabus
Flow of fluids: Types of manometers, Reynolds number and its significance, Bernoulli’s
theorem and its applications, Energy losses, Orifice meter, Venturimeter, Pitot tube and
Rotometer.
Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting
size reduction, principles, construction, working, uses, merits and demerits of Hammer mill,
ball mill, fluid energy mill, Edge runner mill & end runner mill.
Size Separation: Objectives, applications & mechanism of size separation, official standards
of powders, sieves, size separation Principles, construction, working, uses, merits and demerits
of Sieve shaker, cyclone separator, Air separator, Bag filter & elutriation tank.
Mixing: Objectives, applications & factors affecting mixing, Difference between solid and
liquid mixing, mechanism of solid mixing, liquids mixing and semisolids mixing. Principles,
Construction, Working, uses, Merits and Demerits of Double cone blender, twin shell blender,
ribbon blender, Sigma blade mixer, planetary mixers, Propellers, Turbines, Paddles &
Silversion Emulsifier,
Crystallization: Objectives, applications, & theory of crystallization. Solubility curves,
principles, construction, working, uses, merits and demerits of Agitated batch crystallizer,
Swenson Walker Crystallizer, Krystal crystallizer, Vacuum crystallizer. Caking of crystals,
factors affecting caking & prevention of caking.
Evaporation: Objectives, applications and factors influencing evaporation, differences
between evaporation and other heat process. principles, construction, working, uses, merits and
demerits of Steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced
circulation evaporator, triple effect evaporator& Economy of multiple effect evaporator.
Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s law, Heat
transfer by conduction, convection & radiation. Heat interchangers & heat exchangers.
Drying: Objectives, applications & mechanism of drying process, measurements &
applications of Equilibrium Moisture content, rate of drying curve. principles, construction,
working, uses, merits and demerits of Tray dryer, drum dryer spray dryer, fluidized bed dryer,
vacuum dryer, freeze dryer.
Distillation: Objectives, applications & types of distillation. principles, construction, working,
uses, merits and demerits of (lab scale and industrial scale) Simple distillation, preparation of
purified water and water for injection BP by distillation, flash distillation, fractional
distillation, distillation under reduced pressure, steam distillation & molecular distillation
Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids, filter
medias. Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter,
filter leaf, rotary drum filter, Meta filter & Cartridge filter
Centrifugation: Objectives, principle & applications of Centrifugation, principles,
construction, working, uses, merits and demerits of Perforated basket centrifuge, Nonperforated
basket centrifuge, semi continuous centrifuge & super centrifuge.
Plant location, industrial hazards and plant safety: Plant Layout, utilities and services,
Mechanical hazards, Chemical hazards, Fire hazards , explosive hazards and their safety.
Materials of pharmaceutical plant construction, Corrosion and its prevention: Factors
affecting during materials selected for Pharmaceutical plant construction, Theories of
corrosion, types of corrosion and there prevention. Ferrous and nonferrous metals, inorganic
and organic non metals.
Material handling systems: Objectives & applications of Material handling systems, different
types of conveyors such as belt, screw and pneumatic conveyors.
- RGPV CBCS Pathophysiology Syllabus
(a) Basic principles of Cell injury and Adaptation: Introduction, definitions, Homeostasis,
Components and Types of Feed back systems, Causes of cellular injury, Pathogenesis (Cell
membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology
of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia,
Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell
Death Acidosis &Alkalosis, Electrolyte imbalance
(b) Basic mechanism involved in the process of inflammation and repair: Introduction,
Clinical signs of inflammation, Different types of Inflammation, Mechanism of Inflammation–
Alteration in vascular permeability and blood flow, migration of WBC’s, Mediators of
inflammation, Basic principles of wound healing in the skin, Pathophysiology of
Atherosclerosis
(a) Cardiovascular System: Hypertension, congestive heart failure, ischemic heart disease
(angina, myocardial infarction, atherosclerosis and arteriosclerosis)
(b) Respiratory system: Asthma, Chronic obstructive airways diseases.
(c)Renal system: Acute and chronic renal failure.
(a)Haematological Diseases: Iron deficiency, megaloblastic anemia (Vit B12 and folic acid),
sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia
(b) Endocrine system: diabetes, thyroid diseases, disorders of sex hormones
(c)Nervous system: Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression,
schizophrenia and Alzheimer’s disease.
(d) Gastrointestinal system: Peptic Ulcer
Inflammatory bowel diseases, jaundice, hepatitis ( A,B,C,D,E,F) alcoholic liver disease.
(a) Disease of bones and joints: Rheumatoid arthritis, osteoporosis and gout
(b) Principles of cancer: classification, etiology and pathogenesis of cancer
(c) Diseases of bones and joints: Rheumatoid Arthritis, Osteoporosis,Gout
(d) Principles of Cancer: Classification, etiology and pathogenesis of Cancer
Infectious diseases: Meningitis,Typhoid, Leprosy, Tuberculosis, Urinary tract infections
Sexually transmitted diseases: AIDS, Syphilis, Gonorrhea
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