RGPV 3rd Sem CBCS Pharma Syllabus | RGPV B Pharma Syllabus 2nd Year
RGPV 2nd Year 3rd Sem B Pharma syllabus
Now RGPV announced the 2nd year 3rd sem Pharmacy syllabus. In this Scheme there are 6 subjects with practicals. The RGPV CBCS 3rd Sem B Pharma syllabus of 6 subjects are as follows:
- Pharmaceutical Chemistry-iii (Organic Chemistry –Ii ) (Theory)
- Physical Pharmaceutics-ii (Theory)
- Human Anatomy And Physiology-ii (Theory)
- Pharmaceutical Microbiology (Theory)
- Biochemistry (Theory)
- Computer Applications In Pharmacy (Theory)
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Click to >> Download RGPV CBCS 3rd Sem B Pharma Practical Syllabus
- PHARMACEUTICAL CHEMISTRY-III (ORGANIC CHEMISTRY –II
) (Theory) - RGPV 3rd Sem B Pharma syllabus
General methods of preparation and reaction of
compounds superscripted with (*) to be explained. To emphasize on definition, types, classification,
principles/mechanisms, applications, examples and differences:
Benzene and its derivatives
Analytical, synthetic and other evidences in the
derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s
rule.
Reactions of benzene - nitration, sulphonation,
halogenation- reactivity, Friedel crafts alkylationreactivity, limitations, Friedel crafts acylation. Substituents, effect of substituents on reactivity
and orientation of mono substituted benzene compounds towards electrophilic substitution
reaction . Structure and uses of DDT, Saccharin, BHC and
Chloramine
Phenols*
Acidity of phenols, effect of substituent’s on
acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
Aromatic Amines*
Basicity of amines, effect of substituents on
basicity, and synthetic uses of aryl diazonium salts
Fats and Oils
Fatty acids – reactions. Hydrolysis, Hydrogenation, Saponification and
Rancidity of oils, Drying oils. Analytical constants – Acid value, Saponification
value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and
principle involved in their determination.
Polynuclear hydrocarbons
Synthesis, reactions Structure and medicinal uses of Naphthalene,
Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives
Cyclo alkanes*
Stabilities – Baeyer’s strain theory, limitation of
Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of
strainless rings), reactions of cyclopropane and cyclobutane only.
1. Organic Chemistry by Morrison and Boyd
2. Organic Chemistry by I.L. Finar , Volume-I
3. Textbook of Organic Chemistry by B.S. Bahl &
Arun Bahl.
4. Organic Chemistry by P.L.Soni
5. Practical Organic Chemistry by Mann and
Saunders.
6. Vogel’s text book of Practical Organic Chemistry
7. Advanced Practical organic chemistry by
N.K.Vishnoi.
8. Introduction to Organic Laboratory techniques by
Pavia, Lampman and Kriz.
RGPV 3rd Sem B Pharma syllabus PHYSICAL PHARMACEUTICS-II (Theory)
Drug stability:
Reaction kinetics: zero, pseudo-zero, first &
second order, units of basic rate constants, determination of reaction order.
Physical and chemical factors influencing the chemical degradation of pharmaceutical product:
temperature, solvent, ionic strength, dielectric
constant, specific & general acid base
catalysis, Simple numerical problems. Stabilization of
medicinal agents against common reactions like
hydrolysis & oxidation. Accelerated stability testing in dating of pharmaceutical dosage forms.
Photolytic degradation and its prevention
Rheology:
Newtonian systems, law of flow, kinematic
viscosity, effect of temperature, nonNewtonian
systems, pseudoplastic, dilatants, plastic,
thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling
Sphere, rotational viscometers.
Deformation of solids:
Plastic and elastic deformation, Heckel equation,
Stress, Strain, Elastic Modulus
Coarse dispersion:
Suspension, interfacial properties of suspended
particles, settling in suspensions, formulation of suspensions, emulsions
and theories of emulsification. Physical stability of emulsions, preservation of emulsions,
rheological properties of emulsions, phase equilibria and emulsion formulation.
Surface and interfacial phenomenon:
Liquid interface, surface & interfacial
tensions, surface free energy, measurement of surface &
interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB
Scale, solubilisation, detergency, adsorption at solid interface.
Colloidal dispersions:
Classification of dispersed systems & their
general characteristics, size & shapes of colloidal particles, classification of
colloids & comparative account of their general properties. Optical, kinetic & electrical
properties. Effect of electrolytes, coacervation, peptization & protective action.
Recommended Books: (Latest Editions)
1. Physical Pharmacy by Alfred Martin, Sixth
edition
2. Experimental pharmaceutics by Eugene, Parott.
3. Tutorial pharmacy by Cooper and Gunn.
4. Stocklosam J. Pharmaceutical calculations, Lea
& Febiger, Philadelphia.
5. Liberman H.A, Lachman C., Pharmaceutical Dosage
forms, Tablets, Volume-1 to 3, Marcel Dekkar Inc.
6. Liberman H.A, Lachman C, Pharmaceutical dosage
forms. Disperse systems, volume 1, 2, 3.Marcel Dekkar Inc.
7. Physical Pharmaceutics by Ramasamy C, and
Manavalan
RGPV 3rd Sem B Pharma syllabus HUMAN ANATOMY AND PHYSIOLOGY-II (Theory)
Body fluids and blood
Body fluids, composition and functions of blood,
hemopoeisis, formation of hemoglobin, anemia, mechanisms of coagulation, blood grouping, Rh
factors, transfusion, its significance and disorders of blood.
Lymphatic system
Lymphatic organs and tissues, lymphatic vessels,
lymph circulation and functions of lymphatic system Cardiovascular system
Heart – anatomy of heart, blood circulation, blood
vessels, structure and functions of artery, vein and capillaries, elements of conduction system of heart
and heart beat, its regulation by autonomic nervous system, cardiac output, cardiac cycle. Regulation
of blood pressure, pulse, electrocardiogram and disorders of heart.
Digestive system
Anatomy of GI Tract with special reference to
anatomy and functions of stomach, ( Acid production in the stomach, regulation of acid production through
parasympathetic nervous system, pepsin role in protein digestion) small intestine and large intestine,
anatomy and functions of salivary glands, pancreas and liver, movements of GIT, digestion and absorption of
nutrients and disorders of GIT.
Respiratory system
Anatomy of respiratory system with special
reference to anatomy of lungs, mechanism of respiration, regulation of respiration, Lung volumes and
capacities, transport of respiratory gases, artificial respiration, resuscitation methods.
Urinary system
Anatomy of urinary tract with special reference to
anatomy of kidney and nephrons, functions of kidney and urinary tract, physiology of urine formation,
micturition reflex and role of kidneys in acid base balance, role of RAS in kidney and disorders of kidney.
Reproductive system
Anatomy of male and female reproductive system,
Functions of male and female reproductive system, sex hormones, physiology of menstruation,
fertilization, spermatogenesis, oogenesis, pregnancy and parturition.
Introduction to genetics
Chromosomes, genes and DNA, protein synthesis,
genetic pattern of inheritance
Recommended Books (Latest Editions)
1. Essentials of Medical Physiology by K.
Sembulingam and P. Sembulingam. Jaypee brothers medical publishers,
New Delhi.
2. Anatomy and Physiology in Health and Illness by
Kathleen J.W. Wilson, Churchill Livingstone, Newyork
3. Physiological basis of Medical Practice-Best and
Tailor. Williams & Wilkins Co,Riverview,MI USA
4. Text book of Medical Physiology- Arthur C,Guyton
andJohn.E. Hall. Miamisburg, OH, U.S.A.
5. Principles of Anatomy and Physiology by Tortora
Grabowski. Palmetto, GA, U.S.A.
6. Textbook of Human Histology by Inderbir Singh ,
Jaypee brothers medical publishers, New Delhi.
7. Textbook of Practical Physiology by C.L. Ghai ,
Jaypee brothers medical publishers, New Delhi.
8. Practical workbook of Human Physiology by K.
Srinageswari and Rajeev Sharma, Jaypee brother’s medical
publishers, New Delhi.
Reference Books:
1. Physiological basis of Medical Practice-Best and
Tailor. Williams & Wilkins Co, Riverview, MI USA
2. Text book of Medical Physiology- Arthur C,
Guyton and John. E. Hall. Miamisburg, OH, U.S.A.
3. Human Physiology (vol 1 and 2) by Dr. C.C.
Chatterrje ,Academic Publishers Kolka
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RGPV 3rd Sem B Pharma syllabus PHARMACEUTICAL MICROBIOLOGY (Theory)
Introduction, history of microbiology, its
branches, scope and its importance.
Introduction to Prokaryotes and Eukaryotes, Study of ultra-structure and morphological
classification of bacteria, nutritional requirements, raw materials used for culture media and physical
parameters for growth, growth curve, isolation and preservation methods for pure
cultures, cultivation of anaerobes, quantitative measurement of bacterial growth (total & viable
count).
Study of different types of phase
microscopy, dark field microscopy and electron microscopy.
Identification of bacteria using staining
techniques (simple, Gram’s & Acid fast staining) and biochemical tests (IMViC).
Study of principle, procedure, merits,
demerits and applications of Physical, chemical and
mechanical method of sterilization.
Evaluation of the efficiency of sterilization
methods.
Equipments employed in large scale sterilization.
Sterility indicators.
Study of morphology, classification,
reproduction/replication and cultivation of Fungi and
Virus.
Classification and mode of action of disinfectants
Factors influencing disinfection, antiseptics and
their evaluation.
Evaluation of bactericidal & Bacteriostatic.
Sterility testing of products (solids, liquids,
ophthalmic and other sterile products) according to IP, BP and USP.
Designing of aseptic area, laminar flow equipments;
study of different sources of
contamination in an aseptic area and methods of
prevention, clean area classification.
Principles and methods of different microbiological
assay. Methods for standardization of
antibiotics, vitamins and amino acids.
Assessment of a new antibiotic and testing of
antimicrobial activity of a new substance.
General aspects-environmental cleanliness.
Types of spoilage, factors affecting the microbial
spoilage of pharmaceutical products,
sources and types of microbial contaminants,
assessment of microbial contamination and
spoilage.
Preservation of pharmaceutical products using
antimicrobial agents, evaluation of microbial
stability of formulations.
Growth of animal cells in culture, general
procedure for cell culture, Primary, established and transformed cell cultures.
Application of cell cultures in pharmaceutical
industry and research.
Recommended Books (Latest edition)
1. W. B. Hugo and A.D. Russel: Pharmaceutical
Microbiology, Blackwell Scientific
publications, Oxford London.
2. Prescott and Dunn., Industrial Microbiology, 4th
edition, CBS Publishers & Distributors,
Delhi.
3. Pelczar, Chan Kreig, Microbiology, Tata McGraw
Hill edn.
4. Malcolm Harris, Balliere Tindall and Cox:
Pharmaceutical Microbiology.
5. Rose: Industrial Microbiology.
6. Probisher, Hinsdill et al: Fundamentals of
Microbiology, 9th ed. Japan
7. Cooper and Gunn’s: Tutorial Pharmacy, CBS
Publisher and Distribution.
8. Peppler: Microbial Technology.
9. I.P., B.P., U.S.P. - latest editions.
10. Ananthnarayan: Text Book of Microbiology,
Orient-Longman, Chennai
11. Edward: Fundamentals of Microbiology.
12. N.K.Jain: Pharmaceutical Microbiology, Vallabh
Prakashan, Delhi
13. Bergeys manual of systematic bacteriology,
Williams and Wilkins- A Waverly company
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RGPV 3rd Sem B Pharma syllabus BIOCHEMISTRY (Theory)
Carbohydrate metabolism
Glycolysis – Pathway, energetics and significance
Citric acid cycle- Pathway, energetics and
significance
HMP shunt and its significance;
Glucose-6-Phosphate dehydrogenase (G6PD) deficiency
Glycogen metabolism Pathways and glycogen storage
diseases (GSD)
Gluconeogenesis- Pathway and its significance
Hormonal regulation of blood glucose level and
Diabetes mellitus
Biological oxidation
Electron transport chain (ETC) and its mechanism.
Oxidative phosphorylation & its mechanism and
substrate level phosphorylation
Inhibitors ETC and oxidative phosphorylation/Uncouplers
Lipid metabolism
β-Oxidation of saturated fatty acid (Palmitic
acid)
Formation and utilization of ketone bodies;
ketoacidosis
De novo synthesis of fatty acids (Palmitic acid)
Biological significance of cholesterol and conversion
of cholesterol into bile acids, steroid
hormone and vitamin D
Disorders of lipid metabolism:
Hypercholesterolemia, atherosclerosis, fatty liver and obesity.
Amino acid metabolism
General reactions of amino acid metabolism:
Transamination, deamination and decarboxylation,
urea cycle and its disorders
Catabolism of phenylalanine and tyrosine and
their metabolic disorders (Phenyketonuria,
Albinism, alkeptonuria, tyrosinemia)
Synthesis and significance of biological
substances; 5-HT, melatonin, dopamine, noradrenaline,
adrenaline
Catabolism of heme; hyperbillirubinemia and
jaundice
Nucleic acid metabolism and genetic information
transfer
Biosynthesis of purine and pyrimidine nucleotides
Catabolism of purine nucleotides and
hyperuricemia and gout disease
Organization of mammalian genome
Structure of DNA and RNA and their functions
DNA replication (semi conservative model)
Transcription or RNA synthesis
Genetic code, Translation or Protein synthesis
and inhibitors
Biomolecules
Introduction, classification, chemical nature and
biological role of carbohydrate, lipids, nucleic
acids, amino acids and proteins.
Bioenergetics
Concept of free energy, undergone and exergonic
reaction, Relationship between free energy,
enthalpy and entropy, Redox potential.
Energy rich compounds; classification; biological
significances of ATP and cyclic AMP
Enzymes
Introduction, properties, nomenclature and IUB
classification of enzymes
Enzyme kinetics (Michaelis plot, Line Weaver
Burke plot)
Enzyme inhibitors with examples
Regulation of enzymes: enzyme induction and
repression, allosteric enzymes regulation
Therapeutic and diagnostic applications of
enzymes and isoenzymes
Coenzymes –Structure and biochemical functions
Recommended Books (Latest Editions)
1. Principles of Biochemistry by Lehninger.
2. Harper’s Biochemistry by Robert K. Murry, Daryl
K. Granner and Victor W. Rodwell.
3. Biochemistry by Stryer.
4. Biochemistry by D. Satyanarayan and
U.Chakrapani.
5. Textbook of Biochemistry by Rama Rao.
6. Textbook of Biochemistry by Deb.
7. Outlines of Biochemistry by Conn and Stumpf
8. Practical Biochemistry by R.C. Gupta and S.
Bhargavan.
9. Introduction of Practical Biochemistry by David
T. Plummer. (3rd Edition)
10. Practical Biochemistry for Medical students by
Rajagopal and Ramakrishna.
11. Practical Biochemistry by Harold Varley.
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RGPV 3rd Sem B Pharma syllabus COMPUTER APPLICATIONS IN PHARMACY (Theory)
Number system:
Binary number system, Decimal number system, Octal
number system,
Hexadecimal number systems, conversion decimal to
binary, binary to decimal, octal to binary etc, binary addition, binary subtraction – One’s
complement ,Two’s complement method, binary multiplication, binary division.
Concept of Information Systems and Software:
Information
gathering, requirement and feasibility analysis, data flow diagrams, process
specifications, input/output design, process life cycle, planning and managing the project.
Web technologies:
Introduction
to HTML, XML, CSS and Programming languages, introduction to
web servers and Server Products.
Introduction to databases, MYSQL, MS ACCESS,
Pharmacy Drug database.
Application of computers in Pharmacy –
Drug
information storage and retrieval, Pharmacokinetics, Mathematical model in Drug design, Hospital and
Clinical Pharmacy, Electronic Prescribing and discharge (EP) systems, barcode medicine
identification and automated dispensing of drugs, mobile technology and adherence monitoring.
Diagnostic System, Lab-diagnostic System, Patient
Monitoring System, Pharma Information System.
Bioinformatics:
Introduction, Objective of
Bioinformatics, Bioinformatics Databases, Concept of
Bioinformatics, Impact of Bioinformatics in Vaccine
Discovery.
Computers as data analysis in Pre-clinical
development:
Chromatographic dada analysis (CDS), Laboratory Information management System
(LIMS) and Text Information Management System (TIMS).
Recommended books (Latest edition):
1. Computer Application in Pharmacy – William E.
Fassett –Lea and Febiger, 600 South
Washington Square, USA, (215) 922-1330.
2. Computer Application in Pharmaceutical Research
and Development –Sean Ekins – WileyIntescience, A John Willey and Sons, INC., Publication, USA
3. Bioinformatics (Concept, Skills and
Applications) – S. C. Rastogi-CBS Publishers and
Distributiors 4596/1- A, 11 Darya Gani, New Delhi –
110 002(INDIA)
4. Microsoft office Access - 2003, Application
Development Using VBA, SQL Server, DAP and Infopath – Cary N. Prague – Wiley Dreamtech India
(P) Ltd., 4435/7, Ansari Road, Daryagani, New Delhi - 110002
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